WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=5; E=0.62; R=8.07; rawP=0.0004; adjP=0.0033
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
2  ENSG00000150630 NA VEGFC vascular endothelial growth factor C 7424 ENSG00000150630
3  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
4  ENSG00000109906 NA ZBTB16 zinc finger and BTB domain containing 16 7704 ENSG00000109906
5  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851


Database:KEGG pathway       Name:Jak-STAT signaling pathway       ID:04630
C=155; O=4; E=0.29; R=13.57; rawP=0.0002; adjP=0.0033
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
2  ENSG00000113594 NA LIFR leukemia inhibitory factor receptor alpha 3977 ENSG00000113594
3  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
4  ENSG00000112576 NA CCND3 cyclin D3 896 ENSG00000112576


Database:KEGG pathway       Name:Pancreatic cancer       ID:05212
C=70; O=3; E=0.13; R=22.54; rawP=0.0003; adjP=0.0033
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000150630 NA VEGFC vascular endothelial growth factor C 7424 ENSG00000150630
2  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
3  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851


Database:KEGG pathway       Name:Apoptosis       ID:04210
C=87; O=3; E=0.17; R=18.14; rawP=0.0006; adjP=0.0037
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000171552 NA BCL2L1 BCL2-like 1 598 ENSG00000171552
2  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
3  ENSG00000003400 NA CASP10 caspase 10, apoptosis-related cysteine peptidase 843 ENSG00000003400


Database:KEGG pathway       Name:Neurotrophin signaling pathway       ID:04722
C=127; O=3; E=0.24; R=12.42; rawP=0.0019; adjP=0.0079
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
2  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689
3  ENSG00000095015 NA MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 4214 ENSG00000095015


Database:KEGG pathway       Name:Cytokine-cytokine receptor interaction       ID:04060
C=265; O=4; E=0.50; R=7.94; rawP=0.0017; adjP=0.0079
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000049130 NA KITLG KIT ligand 4254 ENSG00000049130
2  ENSG00000150630 NA VEGFC vascular endothelial growth factor C 7424 ENSG00000150630
3  ENSG00000168329 NA CX3CR1 chemokine (C-X3-C motif) receptor 1 1524 ENSG00000168329
4  ENSG00000113594 NA LIFR leukemia inhibitory factor receptor alpha 3977 ENSG00000113594


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=3; E=0.36; R=8.35; rawP=0.0057; adjP=0.0119
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000168329 NA CX3CR1 chemokine (C-X3-C motif) receptor 1 1524 ENSG00000168329
2  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
3  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689


Database:KEGG pathway       Name:Non-small cell lung cancer       ID:05223
C=54; O=2; E=0.10; R=19.48; rawP=0.0048; adjP=0.0119
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
2  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689


Database:KEGG pathway       Name:Inositol phosphate metabolism       ID:00562
C=57; O=2; E=0.11; R=18.45; rawP=0.0053; adjP=0.0119
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000133056 NA PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 5287 ENSG00000133056
2  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851


Database:KEGG pathway       Name:Endometrial cancer       ID:05213
C=52; O=2; E=0.10; R=20.23; rawP=0.0045; adjP=0.0119
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000105851 NA PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 5294 ENSG00000105851
2  ENSG00000118689 NA FOXO3 forkhead box O3 2309 ENSG00000118689




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).